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KMID : 1149120190160020068
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Journal of the Korean Society for Psoriasis
2019 Volume.16 No. 2 p.68 ~ p.72
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A Case of Psoriasiform Eruption in a Pediatric Patient with Inflammatory Bowel Disease treated with Adalimumab
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Jung Chang-Jin
Suh Hyun-Yi
Lee Woo-Jin
Chang Sung-Eun
Lee Mi-Woo
Choi Jee-Ho
Won Chong-Hyun
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Abstract
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Anti-tumor necrosis factors (anti-TNF) including adalimumab used to treat several immune-based diseases paradoxically have been reported to induce new-onset or exacerbation of psoriasiform skin eruptions. While, previous studies have indicated higher co-occurrence of psoriasis and inflammatory bowel disease (IBD) without regard to anti-TNF therapies. Clarifying whether anti-TNF therapies induce psoriasis in IBD patients is important to establish the appropriate treatment plan. Herein, we report a case of psoriasiform eruption in a pediatric patient with IBD treated with adalimumab. A 16-yearold girl, treated with adalimumab due to Crohn’s disease, presented with a 6-month history of multiple erythematous scaly papuloplaques on whole body. Histopathologic examination was compatible with psoriasis. Although the role of adalimumab in occurrence of psoriasiform eruption in this case is unclear, but a recent study reported the incidence of anti-TNF therapy induced psoriasis is higher than that of psoriasis irrelevant to anti-TNF therapy in pediatric patients with IBD.
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KEYWORD
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Adalimumab, Inflammatory bowel disease, Psoriasiform eruption
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